Sean McCarthy, D. Phil.
President and Chief Executive Officer

Sean McCarthy, D. Phil, joined CytomX in 2011 and has more than twenty years of experience in the biotechnology industry encompassing roles in R&D management, business development and financing. Following completion of his post-doctoral training at the DNAX Research Institute (now Merck Palo Alto) Dr. McCarthy held research leadership and program management roles at Millennium Pharmaceuticals where he managed therapeutic protein discovery programs. From Millennium he joined SGX Pharmaceuticals where he spearheaded a wide range of pharma partnerships as vice president, business development. He also served on the SGX management team that led a successful initial public offering in 2006 (SGXP; subsequently acquired by Lilly). Prior to joining CytomX Dr. McCarthy was a transactional partner at Pappas Ventures responsible for investments in therapeutic, medical device and molecular diagnostic companies including LEAD Therapeutics (acquired by Biomarin), TyRx (acquired by Medtronic), Lumena (acquired by Shire). Dr. McCarthy is an author on multiple peer-reviewed scientific publications, issued patents and filed patent applications. He received his B.Sc. in biochemistry and pharmacology at King’s College, University of London; his M.B.A. from the Rady School of Management at University of California, San Diego; and a D. Phil. in cancer biology from St. John’s College, University of Oxford. Dr. McCarthy is a Board member of the California Life Sciences Association.

W. Michael Kavanaugh,  M.D.
Chief Scientific Officer and Head of Research and Non-Clinical Development

Michael Kavanaugh, M.D. joined CytomX in January 2015 as chief scientific officer and head of research and early development. Prior to joining CytomX, Dr. Kavanaugh was senior vice president and chief scientific officer of Five Prime Therapeutics. Since joining the company in 2009, he held multiple positions in research and development and led the growth of the company’s therapeutic pipeline. Before Five Prime, Dr. Kavanaugh served as vice president of Novartis Vaccines & Diagnostics, Inc. and executive director of Oncology Biologics in the Novartis Institutes of Biomedical Research. He joined Novartis in 2006 as part of the company’s acquisition of the Chiron Corporation, where he was vice president and head of antibody and protein therapeutics research. Dr. Kavanaugh received his medical doctorate from Vanderbilt University and his bachelor’s degree in molecular biochemistry and biophysics from Yale University. He completed training in internal medicine, cardiovascular disease and molecular and cellular biology at the University of California, San Francisco and the Cardiovascular Research Institute. Dr. Kavanaugh also currently serves as an attending staff physician at the San Francisco Veterans Administration Medical Center and as an associate clinical professor of medicine at UCSF.

Rachel Humphrey, M.D.
Chief Medical Officer

Rachel Humphrey, M.D., joined CytomX in August 2015. Dr. Humphrey recently held positions as vice president and head of immuno-oncology both at Eli Lilly and at AstraZeneca, where she was responsible for building the immuno-oncology departments and supervising the strategies and designs for all immuno-oncology agents in development. She previously served as vice president of product development at Bristol-Myers Squibb, where she led all aspects of clinical development of the antibody therapy Yervoy™ through the submission of global biologics license applications and global launch. At Bayer, Dr. Humphrey supervised all aspects of the early and late stage clinical development of Nexavar for treatment of renal cell carcinoma. She began her career as an oncology fellow and staff physician at the National Cancer Institute. Dr. Humphrey trained in internal medicine at the Johns Hopkins Hospital, received her medical degree from Case Western Reserve University and her bachelor’s degree from Harvard University.

Bob Goeltz
Chief Financial Officer

Bob Goeltz joined CytomX in 2015 as chief financial officer, bringing more than 15 years of finance experience in the biotechnology industry. Prior to joining CytomX, Mr. Goeltz was chief financial officer of Onyx Pharmaceuticals, which was acquired by Amgen in 2013. Before Onyx, Mr. Goeltz held leadership roles in business development, commercial finance, research and development finance, and corporate accounting at Amgen. He also served as director of finance at Tularik Inc. prior to its acquisition by Amgen in 2004. Mr. Goeltz began his career in the audit practice for Ernst & Young, where he was involved with numerous initial public offerings. Mr. Goeltz earned an M.B.A. from the University of California, Los Angeles Andersen School of Management and a bachelor’s degree in business from Emory University. He also is a certified public accountant (inactive).

Cynthia J. Ladd
Senior Vice President, General Counsel

Cynthia Ladd joined CytomX in 2015 as senior vice president and general counsel. She most recently was an independent consultant to biotechnology companies, supporting corporate growth by advising on corporate strategy, negotiations around collaborations, and clinical and regulatory issues, as well as acting as general counsel. Previously, she was president and chief executive officer of AGY Therapeutics, leading the company through a successful venture round and its transition to a clinical organization. Ms. Ladd also served as senior vice president and general counsel at Pharmacyclics, where she led various operating groups, including regulatory affairs, advised on corporate governance and compliance, structured negotiations for business development activities and led all of the legal activities, including those related to the company’s intellectual property portfolio. Earlier in her career, Ms. Ladd held a number of positions at Genentech, including vice president of corporate law and chief corporate counsel. She began her career as an associate with Wilson, Sonsini, Goodrich & Rosati and Ware & Freidenrich (now DLA Piper). Ms. Ladd received her law degree from Stanford Law School, a master’s degree in animal nutrition and biochemistry from Cornell University and a bachelor’s degree in animal science from Pennsylvania State University.