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Immuno-Oncology Veteran Rachel Humphrey, M.D., Joins CytomX as Chief Medical Officer

Experienced Oncology Leader To Spearhead Clinical Development Of CytomX Probody™ Therapeutic Pipeline

SOUTH SAN FRANCISCO, Calif., August 27, 2015 – CytomX Therapeutics, Inc., a biopharmaceutical company developing Probody™ therapeutics for the treatment of cancer, today announced that Rachel Humphrey, M.D., previously a member of the company’s Board of Directors, has been appointed chief medical officer. Dr. Humphrey formerly led immuno-oncology at Eli Lilly and AstraZeneca, and also oversaw clinical development of Yervoy® (ipilmumab), the first FDA approved checkpoint inhibitor, at Bristol-Myers Squibb and the development of Nexavar (sorafenib) at Bayer.

“Since joining the CytomX board of directors in March, I have been able to see at first-hand the tremendous power of the Probody platform,” said Dr. Humphrey. “I am excited to now be joining the management team to help build a great company that has the potential to make a real difference for patients.”

Added Sean McCarthy, D. Phil., chief executive officer of CytomX, “We were thrilled to have Rachel join the Board earlier this year, and having her now transition to the management team will allow us to benefit even more from her decades of experience in successful oncology product development and registration.

Rachel’s recruitment is a reflection of how we continue to execute towards our vision of transforming lives with safer, more effective therapies.”

Dr. Humphrey recently held positions as vice president and head of immuno-oncology at Eli Lilly and at AstraZeneca, where she was responsible for building the immuno-oncology departments and supervising the strategies and designs for all the immuno-oncology agents in development. She previously served as vice president of product development at Bristol-Myers Squibb, where she led all aspects of the clinical development of Yervoy through the submission of global biologics license applications and global launch. At Bayer, Dr. Humphrey supervised the early and late stage clinical development of Nexavar for treatment of renal cell carcinoma. She began her career as an oncology fellow and staff physician at the National Cancer Institute. Dr. Humphrey trained in internal medicine at the Johns Hopkins Hospital, received her medical degree from Case Western Reserve University and her bachelor’s degree from Harvard University.

In connection with her appointment as chief medical officer, Dr. Humphrey will resign from the Board of Directors of CytomX.