CytomX Therapeutics Announces Second Quarter 2025 Financial Results and Provides Business Update
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- CX-2051 Phase 1 dose expansions on track for data update in Q1 2026.
Phase 2 study initiation in CRC anticipated 1H 2026 -
- Combination dose escalation initiated of CX-801 masked interferon alpha-2b with KEYTRUDA® (pembrolizumab) in patients with advanced melanoma -
- Completed
- Company to host conference call today at
“Q2 2025 was an exciting quarter for CytomX as we announced positive initial clinical results for CX-2051 in advanced colorectal cancer, a very challenging disease to treat. Our data highlight CX-2051’s intentional design as a first-in-class, masked EpCAM-directed ADC with potential to improve upon the standard of care in late-line CRC. We are also delighted to have completed a financing with top-tier investors that enables CytomX to rapidly advance the CX-2051 development program. Looking ahead, we remain highly focused on our next anticipated CX-2051 clinical data update in Q1 2026 and to potentially launching a Phase 2 study in the first half of 2026,” said
Q2 2025 Pipeline Program Updates:
CX-2051 (EpCAM PROBODY Topo-1 ADC)
- Announced positive interim data from ongoing Phase 1 dose escalation study of first-in-class EpCAM Antibody Drug Conjugate (CX-2051) in patients with advanced colorectal cancer (CRC).
- Initiated CX-2051 dose expansions at the 7.2 mg/kg, 8.6 mg/kg, and 10 mg/kg doses, administered every three weeks (Q3W).
- Phase 1 data update in advanced CRC in approximately 70 patients is expected by Q1 2026.
- Planning underway for CX-2051 Phase 2 study initiation in advanced, late-line CRC in 1H 2026.
- Potential to initiate CX-2051 combination studies in earlier lines of CRC therapy in 2026.
- Evaluation ongoing of multiple non-CRC, EpCAM-expressing tumor indications for potential future CX-2051 development.
CX-801 (PROBODY Interferon alpha-2b)
- Phase 1 dose escalation of CX-801 monotherapy continues. Preliminary tumor biomarker, pharmacodynamic (PD) and pharmacokinetic (PK) data evaluating the initial molecular performance of CX-801 monotherapy in the ongoing Phase 1 study are expected in the fourth quarter of 2025.
- In
May 2025 , Phase 1 dose escalation of CX-801 in combination with KEYTRUDA® was initiated. Initial clinical data for the combination therapy in advanced melanoma is anticipated in 2026.
KEYTRUDA® is a registered trademark of
Corporate and Financial:
- Financial:
- Completed
$100 million ($93.4 million net proceeds) underwritten offering of common stock. - CytomX ended the second quarter of 2025 with
$158.1 million of cash, cash equivalents and investments with expected cash runway to the second quarter of 2027.
- Completed
- Research collaborations:
- Presented preclinical data for mRNA encoded masked IL-12 molecule in collaboration with Moderna at AACR Annual Meeting showing potent anti-tumor activity with significantly enhanced tolerability vs. unmasked IL-12 molecule.
- Multiple drug discovery programs continue across our research collaborations with a focus on bispecific immunotherapies, including T-cell engagers. CytomX has research collaborations with
Bristol Myers Squibb , Amgen, Astellas, Regeneron, and Moderna.
Second Quarter 2025 Financial Results:
Cash, cash equivalents and investments totaled
Total revenue was
Total operating expense in the second quarter of 2025 was
Research and development expenses were
General and administrative expenses were
About CytomX Therapeutics
CytomX is a clinical-stage, oncology-focused biopharmaceutical company focused on developing novel conditionally activated, masked biologics designed to be localized to the tumor microenvironment. By pioneering a novel pipeline of localized biologics, powered by its PROBODY® therapeutic platform, CytomX’s vision is to create safer, more effective therapies for the treatment of cancer. CytomX’s multi-modality technology platform has produced therapeutic candidates across multiple treatment modalities including antibody-drug conjugates (ADCs), T-cell engagers, and immune modulators such as cytokines. CytomX’s current clinical-stage pipeline includes CX-2051 and CX-801. CX-2051 is a masked, conditionally activated ADC directed toward epithelial cell adhesion molecule (EpCAM), armed with a topoisomerase-1 inhibitor payload. CX-2051 has potential applicability across multiple EpCAM-expressing epithelial cancers, including CRC, and was discovered in collaboration with ImmunoGen. CX-801 is a masked interferon alpha-2b PROBODY® cytokine with broad potential applicability in traditionally immuno-oncology sensitive as well as insensitive (cold) tumors. CytomX has established strategic collaborations with multiple leaders in oncology, including Amgen, Astellas,
CytomX Therapeutics Forward-Looking Statements
This press release includes forward-looking statements. Such forward-looking statements involve known and unknown risks, uncertainties and other important factors that are difficult to predict, may be beyond our control, and may cause the actual results, performance, or achievements to be materially different from any future results, performance or achievements expressed or implied in such statements, including those related to CX-2051. Accordingly, you should not rely on any of these forward-looking statements, including those relating to the potential benefits, safety and efficacy or progress of CytomX’s or any of its collaborative partners’ product candidates, including CX-2051 and CX-801, the potential benefits or applications of CytomX’s PROBODY® therapeutic platform, CytomX’s or its collaborative partners’ ability to develop and advance product candidates into and successfully complete clinical trials, including the ongoing and planned clinical trials of CX-2051 and CX-801 and the timing of initial and ongoing data availability for our clinical trials, including CX-2051 and CX-801, and other development milestones. Risks and uncertainties that contribute to the uncertain nature of the forward-looking statements include: the unproven nature of CytomX’s novel PROBODY® therapeutic technology; uncertainties around the Company’s ability to raise sufficient funds to carry out its planned research and development; CytomX’s clinical trial product candidates are in the initial stages of clinical development and its other product candidates are currently in preclinical development, and the process by which preclinical and clinical development could potentially lead to an approved product is long and subject to significant risks and uncertainties, including the possibility that the results of preclinical research and early clinical trials, including initial CX-2051 results, may not be predictive of future results; the possibility that CytomX’s clinical trials will not be successful; the possibility that current preclinical research may not result in additional product candidates; CytomX’s dependence on the success of CX-2051 and CX-801; CytomX’s reliance on third parties for the manufacture of the Company’s product candidates; possible regulatory developments in
PROBODY is a
Company Contact:
SVP, Chief Financial Officer
cogden@cytomx.com
Investor Contact:
Precision AQ (formerly Stern Investor Relations)
Stephanie.Ascher@precisionaq.com
Media Contact:
teri@redhousecomms.com
CONDENSED STATEMENTS OF OPERATIONS AND COMPREHENSIVE INCOME (in thousands, except share and per share data) (Unaudited) |
||||||||
| Three Months Ended | ||||||||
| 2025 | 2024 | |||||||
| Revenues | $ | 18,658 | $ | 25,115 | ||||
| Operating expenses: | ||||||||
| Research and development | 13,322 | 25,172 | ||||||
| General and administrative | 6,622 | 8,395 | ||||||
| Total operating expenses | 19,944 | 33,567 | ||||||
| Loss from operations | (1,286 | ) | (8,452 | ) | ||||
| Interest income | 1,178 | 1,971 | ||||||
| Other (expense) income, net | 17 | (2 | ) | |||||
| Loss before income taxes | (91 | ) | (6,483 | ) | ||||
| Provision for income taxes | 63 | 51 | ||||||
| Net Loss | (154 | ) | (6,534 | ) | ||||
| Other comprehensive loss: | ||||||||
| Unrealized gain on investments, net of tax | 34 | 6 | ||||||
| Total comprehensive loss | $ | (120 | ) | $ | (6,528 | |||
| Net loss per share: | ||||||||
| Basic | $ | (0.00 | ) | $ | (0.08 | ) | ||
| Diluted | $ | (0.00 | ) | $ | (0.08 | ) | ||
| Shares used to compute net income per share | ||||||||
| Basic | 129,075,546 | 84,880,632 | ||||||
| Diluted | 129,075,546 | 84,880,632 | ||||||
CONDENSED BALANCE SHEETS (in thousands) |
||||||||
| 2025 | 2024 | |||||||
| (unaudited) | (1) | |||||||
| Assets | ||||||||
| Current assets: | ||||||||
| Cash and cash equivalents | $ | 49,041 | $ | 38,052 | ||||
| Short-term investments | 109,046 | 62,571 | ||||||
| Accounts receivable | 1,869 | 3,103 | ||||||
| Prepaid expenses and other current assets | 4,665 | 3,579 | ||||||
| Total current assets | 164,621 | 107,305 | ||||||
| Property and equipment, net | 1,946 | 2,467 | ||||||
| Intangible assets, net | 510 | 583 | ||||||
| 949 | 949 | |||||||
| Restricted cash | 1,028 | 1,027 | ||||||
| Operating lease right-of-use asset | 5,947 | 8,136 | ||||||
| Other assets | 56 | 66 | ||||||
| Total assets | $ | 175,057 | $ | 120,533 | ||||
| Liabilities and Stockholders' Equity (Deficit) | ||||||||
| Current liabilities: | ||||||||
| Accounts payable | $ | 227 | $ | 1,088 | ||||
| Accrued liabilities | 11,503 | 12,338 | ||||||
| Operating lease liabilities - short term | 5,443 | 5,145 | ||||||
| Deferred revenue, current portion | 22,050 | 67,201 | ||||||
| Total current liabilities | 39,223 | 85,772 | ||||||
| Deferred revenue, net of current portion | 10,241 | 26,862 | ||||||
| Operating lease liabilities - long term | 1,442 | 4,240 | ||||||
| Other long term liabilities | 4,241 | 4,115 | ||||||
| Total liabilities | 55,147 | 120,989 | ||||||
| Commitments and contingencies | ||||||||
| Stockholders' equity (deficit): | ||||||||
| Convertible preferred stock | — | — | ||||||
| Common stock | 2 | 1 | ||||||
| Additional paid-in capital | 788,083 | 691,095 | ||||||
| Accumulated other comprehensive (loss) income | 33 | 27 | ||||||
| Accumulated deficit | (668,208 | ) | (691,579 | ) | ||||
| Total stockholders' equity (deficit) | 119,910 | (456 | ) | |||||
| Total liabilities and stockholders' equity (deficit) | $ | 175,057 | $ | 120,533 | ||||
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(1) The condensed balance sheet as of
Source: CytomX Therapeutics Inc.